Early diagnosis of the syndrome and close long-term follow-up and screening for diabetes and cardiovascular disease are warranted. An opportunity exists for preventive therapy, which should improve the reproductive, metabolic, and cardiovascular risks.
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The development of a new balance in the polycysticovary, solely caused by follicle loss through the process ofovarian ageing, can explain the occurrence of regular cyclesin older patients with PCOS.
It is unknown whether hyperinsulinemia plays a role in the pathogenesis ofpolycystic ovary syndrome (PCOS) in normal weight or thin women. Evidenceindicates that these women are insulin resistant and hyperinsulinemic...
Lifestyle modification without rapid weightloss leads to a reduction of central fat and improved insulinsensitivity, which restores ovulation in overweight infertilewomen with PCOS. Lifestyle modification is the best initialmanagement for obese women seeking to improve their reproductivefunction.
In this study, orlistat produced a significant reduction inweight and total testosterone. The reduction in total testosteronewas similar to that seen after treatment with metformin. Therefore,orlistat may prove to be a useful adjunct in the treatment ofPCOS.
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