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Articles by this Author
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When researchers in Delaware saw diabetic patients shed pounds on a high-fat, carbohydrate-restricted diet, they decided to try it on a group of obese patients with heart disease.
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Pharmacy update - Bad hair day?
Women who complain of being spotty, overweight and hairy may be suffering from a common metabolic disorder that could affect fertility and have long-term health consequences, not just vanity. Vanessa Sherwood looks at polycystic ovarian syndrome
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Advances in the evaluation and treatment of unwanted hair growth (PCOS mentioned)
Whether the etiology is androgen excess or something more benign, excess hair growth negatively impacts quality of life for millions of women. A thorough evaluation is required to uncover underlying causes and provide appropriate treatment.
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Hyperinsulinemia, Not Ovaries, at Core of PCOS
DALLAS -- Polycystic ovary syndrome is in sore need of a new name, Dr. Barbara S. Apgar said at the annual meeting of the American Academy of Family Physicians.
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Hirsutism: An "Alternative" Approach to treatment
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Hirsutism is excessive growth of dark, coarse body and facial hair in women. The abnormal hair growth typically occurs in a pattern seen in adult males. While some body and facial hair growth is normal, women with hirsutism tend to produce elevated levels of male sex hormones called androgens from their ovaries and adrenal glands. Most cases of hirsutism are not excessive and have no underlying cause, but some may indicate the presence of a more serious underlying condition, such as Cushing's syndrome. An estimated 8% of adult women in the United States have hirsutism.
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HIRSUTISM AND OTHER SIGNS OF ANDROGEN EXCESS: PCOS and Acanthosis Nigricans mentioned
Hirsutism is defined as the presence of terminal hairs in skin areas in which hair growth is considered masculine (Fig. 3). Excessive growth of coarse hairs on the lower forearms and lower legs alone does not constitute hirsutism. However, a woman with hirsutism (i.e., terminal hair growth in areas in which hair growth is exclusively masculine) also may note an increase in the pigmentation and growth rate of hairs on the lower forearm and leg. Although hirsutism usually is obvious, it may be important to standardize the examination for future reference with the use of a scoring system (see Fig. 3). Not all hyperandrogenic women have hirsutism (e.g., Asian women rarely do),15 although some patients with obvious hirsutism have normal circulating androgen levels.
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Hair Balding and Polycystic Ovarian Syndrome
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Polycystic ovarian syndrome (PCOS) is often considered a symptom rather than a disease. In other words, many conditions that inhibit ovulation can cause the ovaries to appear polycystic and to secrete more androgens (testosterone) than normal.
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Flutamide for hirsutism
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Flutamide is a potent antiandrogen that strongly binds to androgen receptors on cells in hair follicles and anywhere else in the body. Even though it binds to the cell receptors it does not stimulate the cells into any response.
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The Effect of a Pure Antiandrogen Receptor Blocker, Flutamide, on the Lipid Profile i
The results of this study indicate that 1) flutamide treatment is associated with a significant reduction in total cholesterol, LDL, and triglycerides in young women with PCOS; 2) these effects occur in both obese and lean subjects; 3) the greatest effects of flutamide may be found in those with highest baseline levels of SHBG and androstenedione; and 4) the actions of flutamide on lipid metabolism appear not to be related to changes in circulating adrenaline and noradrenaline levels, glucose metabolism, or insulin sensitivity.
The foremost importance of the present findings is the potential for the development of new therapeutic strategies for the treatment of dyslipidemia. The effects of flutamide on lipid levels are consistent with a significant decline in the risk for development of atherosclerosis and consequent cardiovascular disease.
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Hormonal Effects of Flutamide in Young Women with Polycystic Ovary Syndrome
Anovulation in women with polycystic ovary syndrome (PCOS) is the direct effect of high local androgen concentrations on the ovary. Antiandrogens are substances that prevent androgens from expressing their activity on target tissues. Flutamide is a nonsteroid antiandrogen that has been found effective in hirsute patients, although its mechanism of action is unclear.
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